This is all so new to me. I have never posted on a forum…never needed to. Almost three years ago my daughter, now 15, started having mysterious pain that just got worse and worse. Thankfully almost a year ago we moved near a Children’s Hospital and saw a geneticist and she was diagnosed with EDS. Unfortunately it’s been a down hill slide since. She’s had bones slip, ER visits, and now terrible stomach issues. We just heard about PP and NAC from a new acquaintance who also has a daughter with EDS. We were so excited to try it and jumped right in. We’ve had to stop because her stomach issues have exploded; uncontrollable bm’s, cramping, gas, bloating. The bad thing is that two ER doctors read an xray and told us she was constipated so they had us give her dolcalax and then miralax. I think her stomach is in complete rebellion. She takes Celebrex for pain, Zoloft for anxiety, and Prilosec for acid reflux and stomach upset. Now they have her on bentyl as an anti-spasmodic for the colon and flagyl for a suspected overage of bacteria in the colon. It’s been a week and it’s not working. We started the PP again, one per day, three days ago. So far, no change. My questions are these: How long do we give the PP to work? Does anyone else have these terrible stomach problems and what have you done to fix them? How far do I let the doctors go in looking for what the problem is? She is 15, 5’7” and now weighs around 105 lbs. She is wasting away and I’m scared to death.