I’m so sorry to hear that your daughter is suffering with POTS. :( Although we are all a bit different, can I suggest taking 2-3 capsules first thing in the morning, then waiting 45-60 before eating? This should allowing the body to put everything together sufficiently to stimulate the postganglionic vagus nerve, and to boost acetylcholine for the brain. It took me about a month before my gall bladder, pancreas, stomach acid and bowel movements were consistently normalized. Many of us need to control gut inflammation in conjunction with boosting acetylcholine, too. That’s where zantac, Cromolyn and similar medications come in. Hang in, my friend.