Me too. My left is always bigger, sometimes much. Am on beta blockers for POTS. During any dysautonomic flare, both get bigger, but the left is always my big one. I get cluster migraines on the left (always left), and those make the left pupil look nearly blown out it’s so big. The clusters also give me a speech impediment I don’t usually have, and make left eye tear up-I don’t usually have enough tears to cry, despite punctal plugs. Nose gets stuffy, also left eye gets puffy just above the lid, like a shiner. With the weird speech, it appears very much that I’m having a stroke or TIA (ruled out). No true aura, just an early warning when normal lamplight turns into uncomfortable glare. Pupils diff sizes long as I can remember, the cluster migraines are a new thing. I also can’t tolerate fast flashing lights at night, like police light strobes. Triptan meds help.