Hi there! You are absolutely right! The vagus nerve is a “nicotinic acetylcholinergic nerve”, meaning nicotine can encourage vagus nerve function. Many people who try to quit smoking develop constipation and go back to smoking just for that reason! Parasym Plus is HUGELY helpful for folks who are trying to quit smoking by helping to maintain vagus nerve function (while crossing the blood brain barrier to boost acetylcholine for brain function — something nicotine cannot do). Because the vagus nerve is the antiinflammatory pathway of the body, this can help control inflammation, too. 😉