This is SUCH an interesting question! Yes, many of our signs and symptoms can appear as lupus. Some of us develop autoimmune conditions down the road, and lupus is one I’ve seen (I also see rheumatoid arthritis, dermatomyositis, multiple sclerosis and others). I’m glad that your doctors are looking into it and should you have markers that indicate lupus, they can address these. These autoimmune conditions can cause or exacerbate POTS, and it’s important to know if you fall into this boat. HOWEVER, our condition can also mimic many autoimmune conditions — and this is where it gets tricky. Treatment for problems that mimic autoimmune conditions, but are not truly autoimmune, are different. I’ve seen some doctors even resort to treating us as autoimmune (because it’s the only thing that seems to fit, despite negative lab work). If given a diagnosis of a “presumed autoimmune condition”, I hope you and your doctors always keep their minds open to the possibility that it MAY be something else — they just haven’t figured out what that something else is yet. Please keep us posted — so many of us are in your position. Thank you for posting such a great question! 😉