My C4 is normal too.
C4a (note the ‘a’ for activated) is usually very high in CFS and lots of people with CFS have POTS. As you know complement is associated with inflammatory states.
This shouldn’t be confused with CD4 though, an immune supression marker!
CD4/CD8 ratio is abnormal in CFS also usually.
Chronic inflammation can damage lining to blood vessels and we know what that could cause.
I have very high cytokines and chemokines and high natural killer cell count.
Would be interesting to measure markers of inflammation/infection in people who have CCSVI or think they may have it.
Plus the POTS people. 🙂
This info is GREAT. Thank you for posting. When working on The Driscoll Theory, I was trying to find what started it all… When I figured out that most of us had hydrocephalus, exacerbated by a trigger, I learned that hydrocephalus can make our inflammatory cytokines go nuts. You can imagine how it could get out of control if the stimulus (high ICP) doesn’t stop… If you’ve seen my lectures (or videos of), you’ll see that I’ve been talking about cytokines, mast cells, etc. and how they may very likely be the cause of damage of the vessels, CCSVI being just one result. YES! I agree with you, and am gathering data for folks who’ve had their cytokines/chemokines, etc. Tested. Is it possible for you to send me a copy of your blood work? (I’ll protect your identity, of course). Please feel free to contact me via the contact page, OK? I think we would all be grateful.
BTW, have you had an MRV taken? I’d strongly suggest that (and again, I’d LOVE to see the results. The report will likely say “normal”. The radiologist don’t know how to look for this, yet). Thank you, my friend,