Wow, your case sounds like so many of us — including my own! For those of you who may have missed the interview with Yasmina (the low histamine chef), it is here: http://healinghistamine.com/dr-diana-driscoll-interview-vagus-nerve-and-potsmast-cell-activation/ It was a long journey for answers, but SO worth it in the end. To help figure out if low acetylcholine is a reason for your suffering, it can be helpful to look at symptoms of low levels. We have a “Top 10 symptoms” here:https://vagusnervesupport.com/top-ten-symptoms-of-low-acetylcholine/ The more symptoms, the more likely it is to be at least one of your problems. You already know my story of dramatic gastroparesis, gall bladder dysfunction, and even pancreatitis due to low acetylcholine — all resolved with Parasym Plus. Much of my brain fog and short-term memory problems were for the same reason, yet all of my doctors missed this. What a relief getting it back, however. As far as other products go, there is no other one on the market like it. This is how we were awarded a patent. It took about 3 years to get the mix just right in order to stimulate the (postganglionic) vagus nerve. If the amounts of each ingredient were not just right, it didn’t work! If we mixed it with food, it didn’t work. So it is unique, and I hope it is hugely helpful for you. I suggest starting with 2-3 capsules of Parasym Plus first thing in the morning on an empty stomach. I’d keep your stomach empty for up to an hour (or until you have a bowel movement). If you are like most of us, a bowel movement will be “knocking at your door” in the morning — just like NORMAL people! Imagine that! 😉 I would take the Digestive Enzymes abut 20 -30 minutes before you eat, and the Soothing Digestive Aid as you start to eat, to support your stomach acid production and gall bladder/pancreatic function while Parasym Plus does its magic for your inflammation. It all ends up coming together quite nicely for most of us. As is true with any supplement or medication, as your doctor about its use if you have any questions, and fingers crossed for you!