No you can not use it with opioids because it is a opioid receptor antagonist. Its action on the o receptors stimulates endorphin levels and I believe opioid growth factor. PEA (supplement sold in Europe) can be used with opiods.
Be careful. From what I am reading long term opioid use or very low opioid dosing (I think) can make for more pain. Opioids are god for short term. Pople who use opioids would need to come off of them to get on LDN.
Are you from the Dallas area? My PT just started there. She is VERY good and knows EDS… She is a 3rd level certified dry “needler”, DPT, LMT, & CERT in conditioning.