Hi Shelley, You sound like so many of us! Honestly, I made the doctor rounds, too, and I was never able to get an answer, so I had to work on this myself… I’ll be releasing the medication soon, with an explanation of how it works. The science speaks for itself — you’ll be surprised that no one tried to do this before! It was after visiting the ER with horrible gastroparesis/constipation and no help with Reglan, that I knew I was on my own. Yikes. “Necessity is the mother of invention”, as they say! While you are patiently waiting for this (and I’m meeting with FDA consultants, manufacturers, about 4 attorneys — good grief), please be sure that you rule out the ‘regular stuff’. You may be surprised to learn how many of us have Celiac, diverticulitis or Crohn’s, for example, but go undiagnosed. Honestly, to rule out the ‘regular stuff’, I often will not tell my doctors about being hypermobile. Some are afraid of that diagnosis, don’t feel qualified, or are frightened away. Because I do not have any genetic defects of collagen that they’ve found yet, I’m not even certain that I should be saying I have “EDS”. That implies a genetic defect, right? What if some of my issues (and perhaps yours) are from acquired issues, and therefore are treatable? I believe this has been greatly overlooked as a possibility for us all. Working as fast as I can! Big hug…