Hi Mr. Physics, We are not all the same, so it’s important to understand that we can compare our experiences, but I don’t think anyone here is comfortable with specific advice — does that make sense? Having said that, I will tell you that when I am not certain if a medication is helping or hurting, I start and stop it a few times, and I can usually tell. When I took fludrocortisone, my headache/ neckache was MUCH worse, hinting that it was contributing to my high intracranial pressure. I wonder if your doctor would consider you fiddling with that, also, to see if it is helping or hurting? When I started Z/Z, within about 2 weeks, my orthostatic intolerance was better. I remember wondering if it was a real change or not. When our son was able to go back to school part time after 2 weeks on Z/Z (he was too sick to go to school for three years), we knew histamine was contributing to our problems. Fingers crossed for you that you can also figure out which medications are helping (and which are not). It seems crazy, but often, experimenting is the best way to figure it out. Please let us know how it goes! 😉