It’s interesting to see this post. My 10yo daughter has always had pretty bad reactions to mosquito bites, not as bad as your daughters. But in India, (where we visit every couple of years to see family) she has terrible reactions. The bite grow almost to golf ball size and gets fevers. I didn’t know about my EDS, or hers, until a couple of years ago so I never put the two things together. Also, she is having either sinus infections or bouts of diarrhea every week or two since September and occasionally has bouts of vomiting for no reason. I never put all of these things together until recently, wondering if it’s all due to the EDS or just something that’s weakened her immune system. I see I have a lot of research to do.