Stress, mast cells, pain…. more on hydroxyzine
“Mast Cells and Stress—A Psychoneuroimmunological
Perspective”
“… young boy mistakenly diagnosed
and unsuccessfully treated for epilepsy. When it
was recognized that his seizures were induced by acute
stress and were associated with his mastocytosis, he was
successfully treated with a combination of the anxiolytic
antihistamine hydroxyzine and the tricyclic doxepin. The
efficacy of these compounds may be explained by the fact
that mast cell activation can be inhibited by certain tricyclic
anxiolytic medications, such as amitriptyline and
hydroxyzine82, and benzodiazepines.83 In fact, mast cells
have been reported to express high affinity benzodiazepine
receptors.84,85 Hydroxyzine was recently shown to
inhibit neurogenic inflammation and experimental allergic
encephalomyelitis in rats.86 In humans, hydroxyzine
has been used successfully to treat acute pain87 and remitting-
relapsing MS.88”
http://algonot.com/articles/wp-content/uploads/2010/10/stressmastcells.pdf
On autism and seizures:
http://algonot.com/articles/wp-content/uploads/2012/03/Autism-seizures-JNI-2012.pdf
http://algonot.com/articles/wp-content/uploads/2011/12/Autism-mast-cells-BBA-2012.pdf