Zonisamide and Gabapentin made my hyperadrenergic POTS worse! Also, Florineff made it worse and gave me migraines like 20 days out of 30. Awful! What has helped is Diamox. Migraines are almost completely gone, dizziness and fainting are gone and palpatations and tachycardia are less. Still working on getting those gone too. I started on Welbutrin last week as it helps a lot with hyper POTS. So far I at least am starting to feel better and have more energy, but sleep has gotten worse (which is a side effect during the first few weeks).
If I didn’t live on the west coast I would sign up to get an appt with Dr. Francomano even if it took a year or more. You are so blessed to live where there are great doctors not too far away!