Oh, I also found that B12 helps with pain! Some pain doctors inject B12 into the joint (ouch). I prefer to keep my levels up systemically. 😉 This is expensive and not yet in the EDS literature (but it is in the fibromyalgia literature). Human growth hormone helps me. I started it 10 years ago as sort of an experiment to see if I could keep from falling apart at menopause, as I heard so many of us did. I kept my levels at the upper end of normal. I didn’t realize it was doing anything until I went on a trip for 12 days and didn’t pack it. OMG. After about a week, the pain in my back was horrible. Ironically, I was at the EDS conference and couldn’t even sit still. Needless to say, I went back on it as soon as I got home! You may want to have your levels checked. Thanks and hang in!