Please be sure you and your doctors have ruled out the other reasons for Diamox failure, OK? I have them all listed under “Diamox Pearls” in the book. I can’t tell you how many folks thought Diamox wasn’t working for them, only to realize that it wasn’t prescribed correctly (the wrong form, the wrong dose, their CO2 was too low, etc). The only other reason I’ve seen for it to not be effective is if the pressure is just too high for Diamox to make a significant dent. This happened to me recently (when I got out of the hospital). My pressure was clearly high (I felt like my ear drums were going to explode!), but Diamox didn’t make a difference for a while. As my inflammation calmed down, the pressure reduced, Diamox was then able to make the difference for me. Finally! Another thing that may help you figure out if your pressure is truly low is to look at your head circumferences in the first 18 months of life, should you have those. If you are prone to high ICP, your head circumference should grow too fast, when compared to your weight and height. It’s not a guarantee, but can suggest a tendency to have high pressure. Does that make sense? If your pressure is indeed low, I wonder what your doctors are proposing to do to help you? Do they have any ideas? 😉