I am no expert, (brand new Diamox user myself) but from what I have heard/ learned… the florinef is counterproductive to the Diamox. The florinef may be increasing fluid pressure, which you are trying to reduce with the Diamox. Not sure about the propranolol, as I have no experience with it. I decided against florinef for that reason, I did not want to increase pressure. I had a hard time adjusting to Diamox for the first few days (had wacky side effects), but now I do not have side effects, besides numbness/ tingling in my extremities at times and perhaps an increase in light sensitivity. But for me there is reduction in the back of the head ache and upper neck pain, and increased appetite, and it works as an anti-nausea for me, and helps with my mood swings/ irritability. I take 1 1/2 to 2 sodium bicarbonate pills (650mg each from the pharmacist with out an RX) with each dose and I will take an additional 1-2 sodium bicarb pills through out the day. I had to fiddle with the dosage and now my head tells me when I am due. I try to take it at really regular intervals (I take 4 times a day). I had to tinker around with the dosage until I found what was working best. Again, I am no expert. Others here have said that you should have blood levels watched while adjusting to Diamox.