shnoogals, i believe others on the forum have posted that the numbness/tingling subsides after a while. my wife is also on diamox and is experiencing some tingling. she was initially prescribed the 500 mg capsules as well. her’s were the extended release version (i’m guessing that’s what you have too). we immediately called the prescribing doc and asked that they call in the other form of the med – which they did. i believe Dr. Diana suggested that the regular release tablets work better for her (and others too). that’s what my wife is taking now, and as you’ve heard, you can adjust the dosage with those easily by breaking the tablet. not sure what a normal dose is, but my wife worked her way from 62.5 mg 3x day to 125 mg 3x day. She’s sticking with that for now.