I don’t tell you this to scare you, just to share info. It is a hot topic in autism right now, as it is being linked to autism in some, I believe due to the inability to properly detox. It’s mentioned in the bottom of this abstract. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610366/ “Differences in allele frequency and/or significant gene-gene interactions were found for relevant genes encoding the reduced folate carrier (RFC 80G>A), transcobalamin II (TCN2 776G>C), catechol-O-methyltransferase (COMT 472G>A), methylenetetrahydrofolate reductase (MTHFR 677C>T and 1298A>C), and GST M1. We propose that an increased vulnerability to oxidative stress (endogenous or environmental) may contribute to the development and clinical manifestations of autism.” Another pubmed article http://www.ncbi.nlm.nih.gov/pubmed/19440165 “Results: MTHFR 677T-allele frequency was found to be higher in autistic children compared with nonautistic children (16.3 vs. 6.5%) with 2.79-fold increased risk for autism [95% confidence interval (CI): 1.58-4.93] Conclusion: MTHFR C677T is a risk factor, whereas MTRR A66G and SHMT C1420T polymorphisms reduce risk for autism. MTHFR A1298C acts additively in increasing the risk for autism.” Here is another discussion about it. http://heal-thyself.ning.com/forum/topics/mthfr-c677t-folate I know I have more articles and info saved on my other computer if you are interested I could get you some links. You will have to copy and paste links because they don’t work from this forum.