So true migracie! I was bedridden for much of the day for almost 2 years, just couldn’t make it through the day without lying down all afternoon. This was a result of the constant pain, but also crushing fatigue. I was being actively treated by my neurologist, trying pretty much every migraine treatment out there with very little effect and quite a few medication reactions. So glad you are getting some impact from Zyrtec/Zantac. I was able to try some different antihistamines with a cooperative doctor that didn’t see any harm, and I found that hydroxyzine is my best med. I take 50 mg 4x day, which would completely sedate most people (they use 100 mg pre surgery as a sedative). When it started taking away some of the numbness and tingling, I simply dosed based on when symptoms returned. Sadly the symptoms have exceeded the ability of the hydroxyzine to control them, but it still helps me be somewhat functional. I also took cyproheptadine (Periactin) daily for awhile, which helped a little, but could be contributing to my high prolactin levels so I’ve stopped for now. Cromolyn sodium was a huge help, also. Feel free to contact me for additional help with mast cell stuff. We also have some very active Facebook groups with many knowledgable members.