Hi Trevor, It is sort of hard to follow all of the details here, but I just wanted to mention that CSF is constantly being produced (and drained) in all of us. Thus, if her pressure is building up, it takes more than a one-time dose of pressure-lowering medication to remain with lower ICP. Also, I hope her doctors can check the fluid coming out of her nose for CSF (there are a few ways to do so, but a Beta-transferrin test is the most accurate). It sounds like her neuros are checking her out closely, right? They will be able to determine if there is another cause for seizures beyond high ICP. FYI — have I seen pressure high enough to cause seizures? Absolutely. Is it the only cause? That’s the question her doctors can help with. THEN, it’s a matter of figuring out the best way to keep her pressure at an acceptable level, while someone tries to figure out why it is high (what is the underlying problem?). For many of us, these spikes in ICP can be temporary, and we can avoid brain shunts with proper evaluation/treatment. Please keep us posted! 😉