Nancy, when I first took Parasym Plus, I needed FIVE doses! It was so weird, because within 20-30 minutes I could feel my ability to think (and to be AWAKE) improve. After about an hour and a half I felt like that was all I could do, and I needed to sleep. Instead, I took another dose and BAM — I was back! Over the next few days, I was able to take fewer doses and stayed at three doses a day for quite a while. Eventually, I took two and did fine. If you take it after about 4pm it can keep you awake, we found. Otherwise it is fine. This is what my son needed to begin to absorb nutrients again and he was able to recover from osteoporosis. It was such a scary time, but I’m happy to say it is now behind us. Hang in, my friend. 🙂