What a fascinating question! I am eager to hear from others on this. I would add another question — some of us have stretchy skin, and a skin biopsy indicates abnormal collagen. We may have Classic EDS, or some sort of overlap syndrome — it is hard to know. But if the skin biopsy indicates the abnormal collagen, could those patients be more affected with what you describe? I wonder if you have had a skin biopsy? Thanks for sharing!
Thanks for the reply!
My guess would be that, indeed, if the skin biopsy indicates the abnormal collagen, then the traits I have listed would be (more) observable. In other words, I think that most of the effects of EDS on the reproductive system that I have listed are due to stretchy skin.
Unfortunately, I did not have a skin biopsy. I have seen 2 rheumatologists: one who is very knowledgeable, and who said I have an overlap between classical and hypermobile type, and another who is not very knowledgeable, and who said I have the hypermobility type.
I personally think I fit the classical type more. The reason is that my skin is quite elastic, my hypermobility is very extreme in fingers, hands, and feet, but not much elsewhere, and I experience only a modest amount of dislocations and subluxations, and they are practically pain-free (which is in contrast to the typical hypermobility EDS type).
Currently, I am suspected to have a mutation on COL1A1 or COL1A2, so that I would have an EDS/OI (osteogenesis imperfecta) overlap, since my bone density is very low. These genes are now being sequenced.
As a side note, my sister displays very similar traits to me, and she also seems to have many analogue traits with her reproductive system!