Dr D… since 45% of folks are Alpha Tryptase deficient, I’m not surprised that ppl are not being diagnosed! I think Mast Cell Diseases will prove to be far more common than they are now thought to be.
Deb… I am not aware of any research into Mast Cells and EDS. However, there has been a good bit done on Mast Cells and tissue remodeling. I expect it will take awhile to learn about all the ways Mast Cells are involved.