EDS is short for Ehler-Danlos syndrome, which is the main topic behind this forum, I believe. : )
I am not a medical professional, nor do I know much about antihistamines, as I do not need them, so I cannot give you much advice. I do know that some people with Mast Cell Disorder respond only to specific antihistamines.
Do you have Ehler-Danlos syndrome? The creator of this forum is Dr Diana, and she might be helpful with your problem. Here’s one of her videos: https://www.youtube.com/watch?v=096JbcWLW5c .
Best wishes!