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Our family has symptoms of EDS, hypermobility type. Each family member has a different presentation of joint laxity although shoulders and ribs seem to be most affected. It makes me wonder what process is taking place during fetal development to make some joints more hypermobile than others.
As far as brain stuff goes, our family seems like is has more than our share of anxiety and mild depression. No one has been diagnosed with autism but some could possibly have undiagnosed mild autistic-like behaviors. On the plus side, everyone in the family has tested out with high IQ (all in top 2%). Don’t know if the high IQ is related to the EDS thing or not because the older generation members that are not on the EDS side of the family have high IQs as well.
You are asking some fascinating questions that I hope will be answered sometime in my lifetime!