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I started taking Parasym a few weeks ago but unfortunately I caught a horrible virus from my son so I took a break. Well, I started up again a few days ago and I think it might be working. I say “I think” because I’m cautious of saying it’s working. I’ve tried many, many things to treat my CFS and mycotoxin exposure and nothing worked well for me.
When I first started Parasym I had these weird feelings inside of me about an hour after I took the two pills. So when I re-started taking it, I backed down to one pill, twice daily and I’m not getting the strange feelings. I feel like the changes are subtle, but real – feeling a little more refreshed when I wake up in the morning, less inflamed and more energy. Not huge changes, but changes nonetheless.
What I’m wondering, are these subtle change normal or do others typically feel more dramatic effects?
For the last couple years, I’ve believed the vagus nerve is involved with CFS and other mystery illnesses because it’s the one thing that seems to connect affected organs. In my case, I would get a case of the “yawns” and breathing difficulties, while simultaneously getting major digestive upsets and I wondered what connected the two. I later heard about Dr. Michael VanElzakker’s theory about CFS being an infection of the vagus nerve, which made sense and finally Dr. Dianna and her theory about acetylcholine and the vagus nerve. It would also make sense that researchers haven’t found the cause of these weird diseases if they can’t access the vagus nerve to test for pathogens and if we’re low in acetylcholine (they can’t test for that either?)
Anyway, I find this area of research exciting and thank you Dr. Dianna for the huge part you’re playing in all of this!
I’m so happy you are seeing some benefit. I *think* the more dramatic effects are evident in those of us with more severely low acetylcholine (or more obvious vagus nerve problems). In my case, I got so bad that I couldn’t get out of bed, think, or have a bowel movement. I even started hallucinating (which was horrifying). I hope most of us don’t need to get that bad to enjoy the benefits. And you are right! they can’t test for levels of acetylcholine, sadly. Deficiencies must be recognized by presentation (which can be tough if a patient has 50 symptoms!). 🙂
Dr. D – I’m new to the board and am very intrigued by your research of the Vagus Nerve. Not sure if you are familiar with the Shoemaker / Biotoxin research, but I’m a homozygous 4-3-53 (HLA gene type) and have been suffering for 10 years had a recovery period then last 6 months crashed hard. TGF-Beta 1 went from normal to over 12000 due to suspected mold hit in the last year. My vagus nerve has ALWAYS been central in my illness like it was swollen / inflamed. The problem is so bad it is causing me terrible shortness of breath, food sensitives, disabling fatigue, etc. from HIGH TGF-Beta 1 Its been devastating. As I work to get rid of the toxins through cholestryramine, I’m looking at Parasym Plus to help calm the vagus nerve as I attempt to go through detoxification. The Vagus is the root of many of my terrible symptoms.
Question: Have you noticed anyone from the biotoxin community (mold, lyme) get relief in suppressing the TGF-Beta 1 from PP? Once that marker sky rocketed it has wiped me out.
Best, Rob
Thanks for your hard work.
Welcome, Rob! I hate to hear how long you’ve been suffering, but please know you are not alone. This propensity for abnormal inflammation (including but not limited to TGF-beta) appears to affect much more than the mold/Lyme community and extends into EDS/POTS, CFS/ME, CRPS and many cases of fibromyalgia. The inflammatory cascade is quite complex — one aspect of inflammation triggers another, which triggers another and so on. The vagus nerve is critical to help control most inflammation both by its stimulation of the spleen and by its ability to control the alpha-7 subunit nicotinic acetylcholine receptors on many inflammatory cells. Although I can’t tell you if Parasym Plus will return your cytokine levels to normal, I will say that if your vagus nerve is not functioning well, it is likely impossible to control inflammation and recover normally if you have a propensity for such abnormal inflammation. I hope that explanation helps! 🙂
Welcome, Rob! I hate to hear how long you’ve been suffering, but please know you are not alone. This propensity for abnormal inflammation (including but not limited to TGF-beta) appears to affect much more than the mold/Lyme community and extends into EDS/POTS, CFS/ME, CRPS and many cases of fibromyalgia. The inflammatory cascade is quite complex — one aspect of inflammation triggers another, which triggers another and so on. The vagus nerve is critical to help control most inflammation both by its stimulation of the spleen and by its ability to control the alpha-7 subunit nicotinic acetylcholine receptors on many inflammatory cells. Although I can’t tell you if Parasym Plus will return your cytokine levels to normal, I will say that if your vagus nerve is not functioning well, it is likely impossible to control inflammation and recover normally if you have a propensity for such abnormal inflammation. I hope that explanation helps! 🙂
Thanks for the fast response. Makes complete sense. I will work PP slowly into the detox protocol I’m using to see if it will help minimize die-off or cytokine storms from moving toxins out.
Best, Rob
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