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I have a six year-old son recently diagnosed with EDS Hypermobility. Being new, I have lots of questions, but will start with this one. I’ve seen a few references here to problems some of the ladies have experienced with worsening symptoms when taking progesterone. I also saw a quote from Cincy Children’s Dr. Tinkle’s (who is also my son’s EDS doc) book that stated: ‘It has been known that there is a hormonal influence on joint laxity. The female hormones affect the ligaments at the cellular level altering the production of collagen and the cells that support it [Magnusson, 2007; Hansen, 2008].’.
When I was pregnant with my son I used a lot of progesterone as prescribed by my doc at the time. What I’m just considering the possibility that, with what appears to be a strong connection between progesterone and this condition, if it’s use may somehow be a trigger in utero, possibly if someone is predisposed or otherwise.
Hi Diane, What an interesting question. I can’t say that I have an answer, but I will tell you that with POTS, we certainly get worse with estrogen! Any vasodilator (like estrogen) or HISTAMINE (as in mast cell disease) causes us to feel much sicker, usually. Many of us stop our periods to get by (I stopped my period for 2 years). That helps a lot of us. Progesterone can cause vasoconstriction of the arterioles, which could bring less oxygen to our tissues (including our brains). I don’t believe researchers have it all sorted out yet (as evident by the conflicting articles that we read! What’s a woman to do?). Does anybody else have any thoughts on this? Thanks for a great question! 🙂 Diana
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