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Welcome, Rob! I hate to hear how long you’ve been suffering, but please know you are not alone. This propensity for abnormal inflammation (including but not limited to TGF-beta) appears to affect much more than the mold/Lyme community and extends into EDS/POTS, CFS/ME, CRPS and many cases of fibromyalgia. The inflammatory cascade is quite complex — one aspect of inflammation triggers another, which triggers another and so on. The vagus nerve is critical to help control most inflammation both by its stimulation of the spleen and by its ability to control the alpha-7 subunit nicotinic acetylcholine receptors on many inflammatory cells. Although I can’t tell you if Parasym Plus will return your cytokine levels to normal, I will say that if your vagus nerve is not functioning well, it is likely impossible to control inflammation and recover normally if you have a propensity for such abnormal inflammation. I hope that explanation helps! 🙂
Thanks for the fast response. Makes complete sense. I will work PP slowly into the detox protocol I’m using to see if it will help minimize die-off or cytokine storms from moving toxins out.
Dr. D – I’m new to the board and am very intrigued by your research of the Vagus Nerve. Not sure if you are familiar with the Shoemaker / Biotoxin research, but I’m a homozygous 4-3-53 (HLA gene type) and have been suffering for 10 years had a recovery period then last 6 months crashed hard. TGF-Beta 1 went from normal to over 12000 due to suspected mold hit in the last year. My vagus nerve has ALWAYS been central in my illness like it was swollen / inflamed. The problem is so bad it is causing me terrible shortness of breath, food sensitives, disabling fatigue, etc. from HIGH TGF-Beta 1 Its been devastating. As I work to get rid of the toxins through cholestryramine, I’m looking at Parasym Plus to help calm the vagus nerve as I attempt to go through detoxification. The Vagus is the root of many of my terrible symptoms.
Question: Have you noticed anyone from the biotoxin community (mold, lyme) get relief in suppressing the TGF-Beta 1 from PP? Once that marker sky rocketed it has wiped me out.
Thanks for your hard work.