Welcome, Rob! I hate to hear how long you’ve been suffering, but please know you are not alone. This propensity for abnormal inflammation (including but not limited to TGF-beta) appears to affect much more than the mold/Lyme community and extends into EDS/POTS, CFS/ME, CRPS and many cases of fibromyalgia. The inflammatory cascade is quite complex — one aspect of inflammation triggers another, which triggers another and so on. The vagus nerve is critical to help control most inflammation both by its stimulation of the spleen and by its ability to control the alpha-7 subunit nicotinic acetylcholine receptors on many inflammatory cells. Although I can’t tell you if Parasym Plus will return your cytokine levels to normal, I will say that if your vagus nerve is not functioning well, it is likely impossible to control inflammation and recover normally if you have a propensity for such abnormal inflammation. I hope that explanation helps! 🙂